Communication

Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery†

  1. Wesley Wu,
  2. Sonny C. Hsiao,
  3. Zachary M. Carrico,
  4. Matthew B. Francis Prof.

Article first published online: 17 NOV 2009

DOI: 10.1002/anie.200902426

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 50, pages 9493–9497, December 7, 2009

Additional Information

How to Cite

Wu, W., Hsiao, S., Carrico, Z. and Francis, M. (2009), Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery. Angewandte Chemie International Edition, 48: 9493–9497. doi: 10.1002/anie.200902426

Author Information

  1. Department of Chemistry, University of California, Berkeley and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-1460 (USA), Fax: (+1) 510-643-3079 http://wasabi.cchem.berkeley.edu/

  1. †

    This research was generously supported by the NIH (R01 GM072700). The Bertozzi group is gratefully acknowledged for cell-culture assistance.

Publication History

  1. Issue published online: 30 NOV 2009
  2. Article first published online: 17 NOV 2009
  3. Manuscript Revised: 1 SEP 2009
  4. Manuscript Received: 7 MAY 2009

Funded by

  • NIH. Grant Number: R01 GM072700

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Keywords:

  • antitumor agents;
  • bioconjugation;
  • capsids;
  • drug delivery;
  • viruses

Graphical Abstract

Thumbnail image of graphical abstract

Delivery by Trojan horse: A water-soluble derivative of the chemotherapeutic agent taxol was synthesized with bioconjugation functionality and attached to capsids of the bacteriophage MS2 (see picture). The modified capsids retained their form and released taxol when incubated with MCF-7 cells. The resulting cell-viability levels were similar to those observed upon treatment with free taxol in solution.

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