This research was generously supported by the NIH (R01 GM072700). The Bertozzi group is gratefully acknowledged for cell-culture assistance.
Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery†
Article first published online: 17 NOV 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 50, pages 9493–9497, December 7, 2009
How to Cite
Wu, W., Hsiao, Sonny C., Carrico, Zachary M. and Francis, Matthew B. (2009), Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery. Angew. Chem. Int. Ed., 48: 9493–9497. doi: 10.1002/anie.200902426
- Issue published online: 30 NOV 2009
- Article first published online: 17 NOV 2009
- Manuscript Revised: 1 SEP 2009
- Manuscript Received: 7 MAY 2009
- NIH. Grant Number: R01 GM072700
- antitumor agents;
- drug delivery;
Delivery by Trojan horse: A water-soluble derivative of the chemotherapeutic agent taxol was synthesized with bioconjugation functionality and attached to capsids of the bacteriophage MS2 (see picture). The modified capsids retained their form and released taxol when incubated with MCF-7 cells. The resulting cell-viability levels were similar to those observed upon treatment with free taxol in solution.