Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery


  • This research was generously supported by the NIH (R01 GM072700). The Bertozzi group is gratefully acknowledged for cell-culture assistance.


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Delivery by Trojan horse: A water-soluble derivative of the chemotherapeutic agent taxol was synthesized with bioconjugation functionality and attached to capsids of the bacteriophage MS2 (see picture). The modified capsids retained their form and released taxol when incubated with MCF-7 cells. The resulting cell-viability levels were similar to those observed upon treatment with free taxol in solution.