Communication

Nanostructuring of Patterned Microelectrodes To Enhance the Sensitivity of Electrochemical Nucleic Acids Detection†

  1. Leyla Soleymani1,
  2. Zhichao Fang2,
  3. Xuping Sun2,
  4. Hong Yang2,
  5. Bradford J. Taft1,
  6. Edward H. Sargent Prof.1,
  7. Shana O. Kelley Prof.2

Article first published online: 6 OCT 2009

DOI: 10.1002/anie.200902439

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8457–8460, October 26, 2009

Additional Information

How to Cite

Soleymani, L., Fang, Z., Sun, X., Yang, H., Taft, Bradford J., Sargent, Edward H. and Kelley, Shana O. (2009), Nanostructuring of Patterned Microelectrodes To Enhance the Sensitivity of Electrochemical Nucleic Acids Detection. Angew. Chem. Int. Ed., 48: 8457–8460. doi: 10.1002/anie.200902439

Author Information

  1. 1

    Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S3G4 (Canada)

  2. 2

    Department of Pharmaceutical Sciences and Department of Biochemistry, University of Toronto, Toronto, ON M5S3M2 (Canada)

  1. †

    We acknowledge the support of the Ontario Centres of Excellence, Genome Canada through the Ontario Genomics Institute, the Ontario Ministry of Research and Innovation, and NSERC.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 6 OCT 2009
  3. Manuscript Revised: 17 AUG 2009
  4. Manuscript Received: 7 MAY 2009

Funded by

  • Ontario Centres of Excellence, Genome Canada through the Ontario Genomics Institute
  • Ontario Ministry of Research and Innovation
  • NSERC

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Keywords:

  • biosensors;
  • microchips;
  • microelectrodes;
  • nucleic acids;
  • patterned nanostructures
Thumbnail image of graphical abstract

Take the rough without the smooth: The electrodeposition of patterned metal microelectrodes on a chip-based platform led to biosensors with varying sensitivity according to the degree of surface nanostructuring, which could be controlled systematically (see picture). The sensitivity of microelectrodes with highly nanostructured surfaces was superior to that of smooth microelectrodes.

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