Communication

In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry†

  1. Karl-Christian Schäfer1,
  2. Júlia Dénes3,
  3. Katalin Albrecht2,
  4. Tamás Szaniszló2,
  5. Júlia Balog2,
  6. Réka Skoumal Dr.3,
  7. Mária Katona3,
  8. Miklós Tóth Dr.3,
  9. Lajos Balogh4,
  10. Zoltán Takáts Dr.1,3

Article first published online: 10 SEP 2009

DOI: 10.1002/anie.200902546

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 44, pages 8240–8242, October 19, 2009

Additional Information

How to Cite

Schäfer, K.-C., Dénes, J., Albrecht, K., Szaniszló, T., Balog, J., Skoumal, R., Katona, M., Tóth, M., Balogh, L. and Takáts, Z. (2009), In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry. Angewandte Chemie International Edition, 48: 8240–8242. doi: 10.1002/anie.200902546

Author Information

  1. 1

    Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität, Schubertstraße 60, Haus 16, 35392 Giessen (Germany), Fax: (+49) 641-9934-809

  2. 2

    Massprom Ltd., Rétköz u. 1, 1118 Budapest (Hungary)

  3. 3

    Semmelweis University, Ulloi ut 26, 1083 Budapest (Hungary)

  4. 4

    “Frédéric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene, Anna u. 5, 1221 Budapest (Hungary)

  1. †

    Supported by the Hungarian National Office for Research and Technology (Nanodrug Grant) and the European Research Council (ERC-STG 210356).

Publication History

  1. Issue published online: 13 OCT 2009
  2. Article first published online: 10 SEP 2009
  3. Manuscript Revised: 8 AUG 2009
  4. Manuscript Received: 13 MAY 2009

Funded by

  • Hungarian National Office for Research and Technology (Nanodrug Grant)
  • European Research Council. Grant Number: ERC-STG 210356

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Keywords:

  • biomarkers;
  • cancer diagnostics;
  • mass spectrometry;
  • phospholipids;
  • tissue analysis

Graphical Abstract

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Beam me up: A novel mass spectrometric ionization technique based on rapid evaporation of biological tissues (see picture) can be used to analyze vital tissues during surgical intervention as well as for processed tissue specimens. A tissue identification system based on principal-component analysis was developed. The method differentiates malignant tumor cells from the surrounding healthy tissue.

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