Communication

Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles†

  1. Hong Yang1,
  2. Angela Hui3,
  3. George Pampalakis1,
  4. Leyla Soleymani2,
  5. Fei-Fei Liu3,
  6. Edward H. Sargent2,
  7. Shana O. Kelley1

Article first published online: 6 OCT 2009

DOI: 10.1002/anie.200902577

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8461–8464, October 26, 2009

Additional Information

How to Cite

Yang, H., Hui, A., Pampalakis, G., Soleymani, L., Liu, F.-F., Sargent, Edward H. and Kelley, Shana O. (2009), Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles. Angew. Chem. Int. Ed., 48: 8461–8464. doi: 10.1002/anie.200902577

Author Information

  1. 1

    Department of Pharmaceutical Sciences and Department of Biochemistry, University of Toronto, Toronto, ON M5S3M2 (Canada)

  2. 2

    Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S3G4 (Canada)

  3. 3

    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, Toronto, ON (Canada)

  1. †

    We acknowledge the support of the Ontario Ministry of Research and Innovation, Genome Canada through the Ontario Genomics Institute, and the NSERC.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 6 OCT 2009
  3. Manuscript Revised: 17 AUG 2009
  4. Manuscript Received: 14 MAY 2009

Funded by

  • Ontario Ministry of Research and Innovation
  • Genome Canada through the Ontario Genomics Institute
  • NSERC

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Keywords:

  • biosensors;
  • microchips;
  • microelectrodes;
  • microRNA;
  • nucleic acids
Thumbnail image of graphical abstract

In the time it takes for lunch: An electronic chip featuring nanostructured microelectrodes (NMEs) enables the analysis of microRNA expression profiles in just 30 min in small RNA samples without enzymatic amplification or sequence labeling. The multiplexed chip detects the hybridization of microRNA targets to NME surfaces and provides large electrocatalytic gain through the use of an ultrasensitive redox reporter system (see picture).

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