These authors contributed equally to this work.
Parallel Isotope-Based Quantification of Modified tRNA Nucleosides†
Article first published online: 11 SEP 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 42, pages 7932–7934, October 5, 2009
How to Cite
Brückl, T., Globisch, D., Wagner, M., Müller, M. and Carell, T. (2009), Parallel Isotope-Based Quantification of Modified tRNA Nucleosides. Angew. Chem. Int. Ed., 48: 7932–7934. doi: 10.1002/anie.200902740
We thank the CiPSM Cluster, SFB 749, the Fonds of the German Chemical Industry, and Bayer-Schering for financial support.
- Issue published online: 30 SEP 2009
- Article first published online: 11 SEP 2009
- Manuscript Received: 22 MAY 2009
- CiPSM Cluster
- Fonds of the German Chemical Industry
- bioanalytical methods;
- gene translation;
- isotope labeling;
Modifications make a difference: An isotope-based mass spectrometry method allows the facile and quantitative analysis of modified tRNA nucleosides in various types of cells. This method could be capable of distinguishing between individual cell lines as well as between healthy tissue and cancer cells.