We thank the Skaggs Institute for Chemical Biology for financial support. T.J.D. is a Skaggs postdoctoral fellow.
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Communication
Hydroxy Oximes as Organophosphorus Nerve Agent Sensors†
Article first published online: 15 SEP 2009
DOI: 10.1002/anie.200902820
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Dale, T. and Rebek, J. (2009), Hydroxy Oximes as Organophosphorus Nerve Agent Sensors. Angewandte Chemie International Edition, 48: 7850–7852. doi: 10.1002/anie.200902820
- †
Publication History
- Issue published online: 30 SEP 2009
- Article first published online: 15 SEP 2009
- Manuscript Revised: 9 JUL 2009
- Manuscript Received: 26 MAY 2009
Funded by
- Skaggs Institute for Chemical Biology
Keywords:
- arylisoxazoles;
- fluorescence;
- nerve agents;
- oximes;
- sensors
Graphical Abstract
Find and destroy: A series of oximes were constructed to simultaneously detect and detoxify organophosphorus-based nerve agents. They function as optical sensors employing the oxime reactivity and incorporating a β-hydroxyl group to undergo an intramolecular cyclization from the intermediate oxime–organophosphorus species. The generated isoxazole produces an enhanced fluorescent signal that reports on the presence and destruction of the nerve agent.