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Chiral Calcium Catalysts with Neutral Coordinative Ligands: Enantioselective 1,4-Addition Reactions of 1,3-Dicarbonyl Compounds to Nitroalkenes

Authors

  • Tetsu Tsubogo,

    1. Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division ERATO, Japan Science Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Yasuhiro Yamashita Dr.,

    1. Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division ERATO, Japan Science Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Shū Kobayashi Prof. Dr.

    1. Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division ERATO, Japan Science Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • This work was partially supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), the Global COE Program (Chemistry Innovation through Cooperation of Science and Engineering), the University of Tokyo, and MEXT (Japan). T.T. thanks the JSPS Research Fellowship for Young Scientists.

Abstract

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Salt of the earth: The first chiral, coordinative alkaline earth metal catalysts have been developed. These catalysts effectively promote catalytic asymmetric additions of β-dicarbonyl compounds to nitroalkenes in high yields with high enantioselectivities (up to 96 %).

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