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Keywords:

  • asymmetric allylic alkylation;
  • natural products;
  • palladium;
  • quaternary carbon centers
Thumbnail image of graphical abstract

Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolactone C and (−)-biyouyanagin A in only six (20 % overall yield) and seven (8 % overall yield) steps, respectively. The enantiomers of these natural products were also prepared by exploiting the same methodology.