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Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (−)-Biyouyanagin A

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This article is corrected by:

  1. Errata: Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (−)-Biyouyanagin A Volume 48, Issue 49, 9211, Article first published online: 17 November 2009

  • We are grateful for the financial support provided by the Basic Research Program (973 Program) of China (grant no. 2010CB833203) and the National Natural Science Foundation of China (grant nos. 20621091 and 20772050). We thank Mingji Dai (Columbia University) for helpful discussions.

Abstract

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Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolactone C and (−)-biyouyanagin A in only six (20 % overall yield) and seven (8 % overall yield) steps, respectively. The enantiomers of these natural products were also prepared by exploiting the same methodology.

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