Highly Efficient and Chemoselective Peptide Ubiquitylation

Authors


  • This work was supported by the Edmond J. Safra Foundation and Marc Rich Foundation (A.B.), and by a grant from the Swiss National Science Foundation (H.A.L., 301000).

Abstract

original image

Loving kiss of death: A highly efficient and chemoselective method for ubiquitylation of peptides using δ-mercaptolysine to assist isopeptide formation between the ε-NH2 of the lysine residue and the activated C-terminal glycine of ubiquitin (Ub) is presented.

Ancillary