Highly Efficient and Chemoselective Peptide Ubiquitylation


  • This work was supported by the Edmond J. Safra Foundation and Marc Rich Foundation (A.B.), and by a grant from the Swiss National Science Foundation (H.A.L., 301000).


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Loving kiss of death: A highly efficient and chemoselective method for ubiquitylation of peptides using δ-mercaptolysine to assist isopeptide formation between the ε-NH2 of the lysine residue and the activated C-terminal glycine of ubiquitin (Ub) is presented.