Communication

Methionine Can Favor DNA Platination by trans-Coordinated Platinum Antitumor Drugs†

  1. Chan Li1,
  2. Zhanyong Li1,
  3. Einar Sletten Prof.2,
  4. Fabio Arnesano Dr.3,
  5. Maurizio Losacco Dr.3,
  6. Giovanni Natile Prof.3,
  7. Yangzhong Liu Prof.1

Article first published online: 6 OCT 2009

DOI: 10.1002/anie.200902948

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8497–8500, October 26, 2009

Additional Information

How to Cite

Li, C., Li, Z., Sletten, E., Arnesano, F., Losacco, M., Natile, G. and Liu, Y. (2009), Methionine Can Favor DNA Platination by trans-Coordinated Platinum Antitumor Drugs. Angew. Chem. Int. Ed., 48: 8497–8500. doi: 10.1002/anie.200902948

Author Information

  1. 1

    Department of Chemistry, University of Science and Technology of China, Hefei Anhui, 230026 (China), Fax: (+86) 551-360-0874

  2. 2

    Department of Chemistry, University of Bergen, Allegt. 41, 5007 Bergen (Norway)

  3. 3

    Dipartimento Farmaco-Chimico, University of Bari via E. Orabona 4, 70125 Bari (Italy)

  1. †

    This work was supported by the National Basic Research Program of China (973 Program, 2009CB918804), the Cultivation Fund of the Key Scientific and Technical Innovation Project, the Ministry of Education of China (No. 707036), NSFC (No. 20873135), and the University of Bari. Y.L. thanks the Chinese Academy of Sciences for the One Hundred Talent Project.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 6 OCT 2009
  3. Manuscript Revised: 30 JUL 2009
  4. Manuscript Received: 2 JUN 2009

Funded by

  • National Basic Research Program of China. Grant Number: 2009CB918804
  • Ministry of Education of China. Grant Number: 707036
  • NSFC. Grant Number: 20873135
  • Chinese Academy of Sciences

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Keywords:

  • antitumor agents;
  • DNA;
  • kinetics;
  • platinum
Thumbnail image of graphical abstract

It happens at the Met: The DNA platination rate is substantially enhanced by methionine binding to trans-coordinated platinum antitumor drugs (see scheme). Platinum–methionine intermediates were also formed in a cell system and could play a major role in the mechanism of action of trans compounds.

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