We are indebted to the DFG (Deutsche Forschungsgemeinschaft) for financial support.
Entirely Artificial Signal Transduction with a Primary Messenger†
Article first published online: 19 SEP 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 43, pages 8001–8005, October 12, 2009
How to Cite
Bernitzki, K. and Schrader, T. (2009), Entirely Artificial Signal Transduction with a Primary Messenger. Angew. Chem. Int. Ed., 48: 8001–8005. doi: 10.1002/anie.200902973
- Issue published online: 7 OCT 2009
- Article first published online: 19 SEP 2009
- Manuscript Received: 2 JUN 2009
- DFG (Deutsche Forschungsgemeinschaft)
- host–guest systems;
- signal transduction;
- steroidal lipids
I saw the sign: An artificial system allows messenger-induced transmembrane signaling. External addition of a primary messenger molecule (DET, see picture) leads to formation of a heterodimeric complex of transmembrane units bearing tryptophan–dansyl (Trp–Dan) donor–acceptor pairs, which in turn stimulates a strong FRET on the opposite side of the membrane.