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Keywords:

  • amphiphiles;
  • FRET;
  • host–guest systems;
  • signal transduction;
  • steroidal lipids
Thumbnail image of graphical abstract

I saw the sign: An artificial system allows messenger-induced transmembrane signaling. External addition of a primary messenger molecule (DET, see picture) leads to formation of a heterodimeric complex of transmembrane units bearing tryptophan–dansyl (Trp–Dan) donor–acceptor pairs, which in turn stimulates a strong FRET on the opposite side of the membrane.