Entirely Artificial Signal Transduction with a Primary Messenger


  • We are indebted to the DFG (Deutsche Forschungsgemeinschaft) for financial support.


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I saw the sign: An artificial system allows messenger-induced transmembrane signaling. External addition of a primary messenger molecule (DET, see picture) leads to formation of a heterodimeric complex of transmembrane units bearing tryptophan–dansyl (Trp–Dan) donor–acceptor pairs, which in turn stimulates a strong FRET on the opposite side of the membrane.