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Keywords:

  • carbocycles;
  • heterocycles;
  • hydroarylation;
  • Lewis acids;
  • propargylic esters
Thumbnail image of graphical abstract

Doubling the bet: Two C[BOND]H bonds become functionalized upon exposure of ω-aryl propargylic tosylates to Sc(OTf)3 (see scheme). The reaction involves a new domino process that can tolerate both electron-withdrawing and -donating substituents on the arene unit. Different carbo- and heterocyclic frameworks can be assembled by using this approach to formally conquer the hydroarylation process.