Communication

The Active Site of an Enzyme Can Host Both Enantiomers of a Racemic Ligand Simultaneously†

  1. Matthias Mentel Dr.3,4,5,
  2. Wulf Blankenfeldt Dr.1,
  3. Rolf Breinbauer Prof. Dr.2,3,4

Article first published online: 28 OCT 2009

DOI: 10.1002/anie.200902997

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 48, pages 9084–9087, November 16, 2009

Additional Information

How to Cite

Mentel, M., Blankenfeldt, W. and Breinbauer, R. (2009), The Active Site of an Enzyme Can Host Both Enantiomers of a Racemic Ligand Simultaneously. Angew. Chem. Int. Ed., 48: 9084–9087. doi: 10.1002/anie.200902997

Author Information

  1. 1

    Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany), Fax: (+49) 231-133-2399

  2. 2

    Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, 8010 Graz (Austria), Fax: (+43) 316-873-8740

  3. 3

    Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)

  4. 4

    Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, 04103 Leipzig (Germany)

  5. 5

    European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg (Germany)

  1. †

    This work was supported by the Max Planck Society, the Bioband of TU Dortmund (R.B. and W.B.), the Deutsche Forschungsgemeinschaft (grant BL587 to W.B.), and the University of Leipzig (R.B.). W.B. thanks Roger S. Goody for his support. We thank Dmitri V. Mavrodi and Linda S. Thomashow for the expression plasmid and Isha Himani Jain for performing crystallization experiments. The help of the X-ray communities at the MPI of Molecular Physiology, the MPI for Medical Research, and the beamline staff at beamline X10SA of the Swiss Light Source with data collection is gratefully acknowledged.

Publication History

  1. Issue published online: 11 NOV 2009
  2. Article first published online: 28 OCT 2009
  3. Manuscript Received: 3 JUN 2009

Funded by

  • Max Planck Society
  • TU Dortmund
  • Deutsche Forschungsgemeinschaft. Grant Number: BL587

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