Communication

The Continuous-Flow Synthesis of Ibuprofen†

  1. Andrew R. Bogdan2,
  2. Sarah L. Poe2,
  3. Daniel C. Kubis2,
  4. Steven J. Broadwater2,
  5. D. Tyler McQuade1

Article first published online: 6 OCT 2009

DOI: 10.1002/anie.200903055

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8547–8550, October 26, 2009

Additional Information

How to Cite

Bogdan, Andrew R., Poe, Sarah L., Kubis, Daniel C., Broadwater, Steven J. and McQuade, D. Tyler. (2009), The Continuous-Flow Synthesis of Ibuprofen. Angew. Chem. Int. Ed., 48: 8547–8550. doi: 10.1002/anie.200903055

Author Information

  1. 1

    Department of Chemistry and Biochemistry, Florida State University, Chemical Sciences Laboratory, Tallahasee, FL 32306 (USA), Fax: (+1) 850-644-8281

  2. 2

    Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY 14853 (USA)

  1. †

    D.T.M. acknowledges NSF SGER, ARO (grant no. W911NF-06-1-0315), NSF (CHE-0809261), and Florida State University for financial support.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 6 OCT 2009
  3. Manuscript Received: 6 JUN 2009

Funded by

  • NSF SGER
  • ARO. Grant Number: W911NF-06-1-0315
  • NSF. Grant Number: CHE-0809261
  • Florida State University

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Keywords:

  • continuous processing;
  • flow chemistry;
  • microreactors;
  • reactor design;
  • synthetic methods
Thumbnail image of graphical abstract

Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.

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