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The Continuous-Flow Synthesis of Ibuprofen


  • D.T.M. acknowledges NSF SGER, ARO (grant no. W911NF-06-1-0315), NSF (CHE-0809261), and Florida State University for financial support.


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Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.