The frontispiece photographs are used with permission and we are grateful to the following sources: Feverfew: Creative Commons Copyright, Vsion, 2005. Arnica Montana, Peter Longatti, Copyright, used with permission. Paeony: Tony Robinson, West Halton, Copyright, used with permission.
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Review
The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches†
Article first published online: 24 NOV 2009
DOI: 10.1002/anie.200903108
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Kitson, Russell R. A., Millemaggi, A. and Taylor, Richard J. K. (2009), The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches. Angew. Chem. Int. Ed., 48: 9426–9451. doi: 10.1002/anie.200903108
- †
Publication History
- Issue published online: 30 NOV 2009
- Article first published online: 24 NOV 2009
- Manuscript Received: 9 JUN 2009
- Abstract
- Article
- References
- Cited By
Keywords:
- bioactivity;
- biosynthesis;
- natural products;
- α-alkylidene-γ-butyrolactones;
- α-methylene-γ-butyrolactones
Abstract
The amount of research activity concerning α-methylene-γ-butyrolactones and α-alkylidene-γ-butyrolactones has increased dramatically in recent years. This Review summarizes the structural types, biological activities, and biosynthesis of these compounds, concentrating on publications from the past 10 years. Traditional approaches to α-methylene-γ-butyrolactones and α-alkylidene-γ-butyrolactones are then reviewed together with novel approaches, including those from our own research group, reported more recently.