Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates


  • The authors gratefully acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG AR376/2-1, DFG Uh 88/8-1) and the Volkswagen-Stiftung.


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More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one-step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.