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Exploiting Tautomerism for Switching and Signaling


  • The work was supported by The Bulgarian Science Found (projects TK-X-1716 and UNA-17/2005) and The Swiss National Science Foundation (JRP IB7320-110961/1).


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Good form: Attaching a flexible piperidine unit to 4-(phenyldiazenyl)naphthalen-1-ol allows construction of a tautomeric switch, where directed shift of the tautomeric equilibrium can be achieved through protonation and deprotonation (see picture). The developed molecular switch shows acceptable complexation with small alkali- and alkaline-earth-metal ions and forms a promising base for further development of effective molecular sensors.