Communication

Template-Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds†

  1. Linda A. Stearns1,
  2. Rahul Chhabra2,
  3. Jaswinder Sharma2,
  4. Yan Liu Prof.2,
  5. William T. Petuskey Prof.3,
  6. Hao Yan Prof.2,
  7. John C. Chaput Prof.1

Article first published online: 30 SEP 2009

DOI: 10.1002/anie.200903319

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8494–8496, October 26, 2009

Additional Information

How to Cite

Stearns, Linda A., Chhabra, R., Sharma, J., Liu, Y., Petuskey, William T., Yan, H. and Chaput, John C. (2009), Template-Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds. Angew. Chem. Int. Ed., 48: 8494–8496. doi: 10.1002/anie.200903319

Author Information

  1. 1

    Center for BioOptical Nanotechnology, The Biodesign Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 (USA), Fax: (+1) 480-727-0396

  2. 2

    Center for Single Molecule Biophysics, The Biodesign Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 (USA), Fax: (+1) 480-727-2378

  3. 3

    Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 (USA)

  1. †

    This work was supported by a grant from the Office of Naval Research (N000140710194G) to H.Y. and J.C.C. We gratefully acknowledge use of facilities in the Leroy Eyring Center for Solid State Science (CSSS) at ASU.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 30 SEP 2009
  3. Manuscript Revised: 30 JUL 2009
  4. Manuscript Received: 19 JUN 2009

Funded by

  • Office of Naval Research. Grant Number: N000140710194G

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Keywords:

  • DNA;
  • inorganic nanostructures;
  • inorganic-binding peptides;
  • nanoparticles;
  • nanotechnology
Thumbnail image of graphical abstract

DNA origami: A DNA nanotube containing gold-binding peptides can nucleate nanoparticles of a discrete size from soluble chemical precursors. The peptide–DNA nanostructure was used to direct the assembly of an inorganic nanostructure, with gold nanoparticles distributed along the surface of the DNA nanotube (see picture). The resulting nanostructure is an important step forward in the synthesis of programmable inorganic materials by self-assembly.

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