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Keywords:

  • bioorganic chemistry;
  • carbohydrates;
  • DNA;
  • HIV;
  • peptide nucleic acids
Thumbnail image of graphical abstract

All under control: The programmability of hybridization has been utilized to generate a combinatorial library of structures that emulate the topologies of complex carbohydrates interacting with an antibody that shows broad-spectrum activity against HIV. This simple method involves attaching oligosaccharides tagged with peptide nucleic acids onto DNA templates in a controlled manner (see schematic picture).