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Keywords:

  • asymmetric catalysis;
  • chiral Brønsted acids;
  • Friedel–Crafts alkylation;
  • indoles;
  • sequential catalysis
Thumbnail image of graphical abstract

A synthetic shortcut: A highly efficient cascade reaction (see scheme) led to polycyclic indoles with excellent enantioselectivity. The combination of the two steps through sequential catalysis enables the use of more readily available starting materials and makes the synthesis more practical. Boc=tert-butoxycarbonyl.