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Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/Intramolecular Friedel–Crafts Alkylation under Sequential Catalysis

Authors

  • Quan Cai,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-5492-5087
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  • Zhuo-An Zhao,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-5492-5087
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  • Shu-Li You Prof. Dr.

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-5492-5087
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  • We thank the National Natural Science Foundation of China (20732006, 20821002), the National Basic Research Program of China (973 Program 2009CB825300), and the Chinese Academy of Sciences for generous financial support.

Abstract

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A synthetic shortcut: A highly efficient cascade reaction (see scheme) led to polycyclic indoles with excellent enantioselectivity. The combination of the two steps through sequential catalysis enables the use of more readily available starting materials and makes the synthesis more practical. Boc=tert-butoxycarbonyl.

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