We thank Science Foundation Ireland for the award of a postdoctoral scholarship (054/RFP4/CHE/0075) for V.C. and the Irish Research Council for Science Engineering and Technology (RS/2006/6) for a grant to M.A. We also acknowledge financial support from the Centre for Synthesis and Chemical Biology, which was funded by the Higher Education Authority’s Programme for Research in Third-Level Institutions (PRTLI).
First Regio- and Enantioselective Chromium-Catalyzed Homoallenylation of Aldehydes†
Article first published online: 1 OCT 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 48, pages 9152–9155, November 16, 2009
How to Cite
Coeffard, V., Aylward, M. and Guiry, Patrick J. (2009), First Regio- and Enantioselective Chromium-Catalyzed Homoallenylation of Aldehydes. Angew. Chem. Int. Ed., 48: 9152–9155. doi: 10.1002/anie.200903647
- Issue published online: 11 NOV 2009
- Article first published online: 1 OCT 2009
- Manuscript Revised: 7 SEP 2009
- Manuscript Received: 3 JUL 2009
- Irish Research Council for Science Engineering and Technology. Grant Number: RS/2006/6
- Higher Education Authority’s Programme for Research
- asymmetric catalysis;
Game, set, and match: The first regio- and enantioselective version of the title reaction is described. The chiral catalyst prepared in situ from CrCl3 and a non-C2-symmetric bis(oxazoline) ligand 1 affords the valuable chiral β-allenols regioselectively in good yields with excellent ee values. R=aryl, alkyl.