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Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment

Authors


  • This work was supported by the National Institutes of Health (GM054111 and GM038047), the Center of Cancer Nanotechnology Excellence (U54A119341), and the CDMRP Breast Cancer Research Program (BC073413 and BC076723). Thanks to Prof. David H. Thompson (Purdue University) for providing folate-PEG3350-DSPE, Rebecca Marvin for help with ICP-MS, Prof. Robert C. MacDonald for critical reading, Sang-Min Lee and Dr. Mala Shanmugam for advice.

Abstract

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Two in one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtII–AsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

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