Fluorescence is ON and transcriptional control is OFF when the guanidinium-modified zinc phthalocyanine Zn-DIGP binds a G-quadruplex DNA from the c-Myc promoter. With an equilibrium dissociation constant Kd of less than 2 nM, this interaction is the strongest binding interaction between a G-quadruplex structure and a small molecule reported to date.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.