Communication

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens†

  1. Stefaan De Koker Dr.2,
  2. Bruno G. De Geest Dr.1,
  3. Satwinder K. Singh4,
  4. Riet De Rycke2,3,
  5. Thomas Naessens2,
  6. Yvette Van Kooyk Prof.4,
  7. Jo Demeester Prof.5,
  8. Stefaan C. De Smedt Prof.5,
  9. Johan Grooten Prof.2

Article first published online: 6 OCT 2009

DOI: 10.1002/anie.200903769

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 45, pages 8485–8489, October 26, 2009

Additional Information

How to Cite

De Koker, S., De Geest, Bruno G., Singh, Satwinder K., De Rycke, R., Naessens, T., Van Kooyk, Y., Demeester, J., De Smedt, Stefaan C. and Grooten, J. (2009), Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens. Angew. Chem. Int. Ed., 48: 8485–8489. doi: 10.1002/anie.200903769

Author Information

  1. 1

    Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University (Belgium)

  2. 2

    Department of Biomedical Molecular Biology, Ghent University (Belgium)

  3. 3

    Department for Molecular Biomedical Research, VIB, Ghent (Belgium)

  4. 4

    Department of Molecular Cell Biology and Immunology, Medical Centre, Vrije Universiteit Amsterdam (The Netherlands)

  5. 5

    Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University (Belgium)

  1. †

    B.G.D.G. thanks the FWO Vlaanderen for a postdoctoral scholarschip.

Publication History

  1. Issue published online: 20 OCT 2009
  2. Article first published online: 6 OCT 2009
  3. Manuscript Received: 9 JUL 2009

Funded by

  • FWO Vlaanderen

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (714K)

Keywords:

  • antigens;
  • capsules;
  • dendritic cells;
  • polyelectrolytes
Thumbnail image of graphical abstract

Stand and deliver: Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus allowing DCs to efficiently process encapsulated antigen.

View Full Article with Supporting Information (HTML) Get PDF (714K)