Consecutive Formation of G-Quadruplexes in Human Telomeric-Overhang DNA: A Protective Capping Structure for Telomere Ends


  • This work was partially supported by a Grant-in-Aid for Specially Promoted Research from the Ministry of Education, Science, Sports, Culture, and Technology (Japan) (18001001). Support by the Global COE Program for Chemistry Innovation through Cooperation of Science and Engineering is also acknowledged.


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The end of the line: Structural studies demonstrate the consecutive formation of G-quadruplexes in human single-stranded telomeric-overhang DNA. A higher-order DNA G-quadruplex structure was found to protect DNA double-strand ends from being recognized as double-strand breaks and to direct against nuclease hydrolysis, suggesting that the superhelix structure may provide protective “capping” for the telomere ends.