A Single Slow Electron Triggers the Loss of Both Chlorine Atoms from the Anticancer Drug Cisplatin: Implications for Chemoradiation Therapy


  • This work was supported by the DFG, the Fonds der Chemischen Industrie, the Freie Universität Berlin, and the Polish Ministry of Science and Higher Education. J.K. acknowledges support from the EU through the COST action CM0601 (ECCL).


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Leaner, meaner cisplatin: Dissociative electron attachment to the anticancer drug cisplatin (1) shows intense resonances at very low energies, which result in Pt[BOND]Cl bond cleavage. A single low-energy electron can trigger the loss of both chlorine atoms from cisplatin (see scheme), thereby forming [Pt(NH3)2]. This complex is the reactive intermediate to form cisplatin–DNA adducts, which consequently inhibit DNA replication.