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Keywords:

  • alkaloids;
  • antitumor agents;
  • biomimetic synthesis;
  • cyclopamine;
  • natural products
Thumbnail image of graphical abstract

A biomimetic synthesis of the potent anticancer drug cyclopamine that features a C[BOND]H activation/hydroxylation and a ring contraction/expansion is described by A. Giannis and co-workers in their Communication on page 7911 ff. The picture shows the structure of cyclopamine, the first inhibitor of hedgehog signaling (discovered in drosophilia); Veratrum californicum; a cyclopic sheep; and Homer, who first reported a cyclops in the Odyssey.