Advertisement

Cover Picture: Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach (Angew. Chem. Int. Ed. 42/2009)

Authors

  • Athanassios Giannis Prof. Dr.,

    1. Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig (Germany), Fax: (+49) 341-973-6599
    Search for more papers by this author
  • Philipp Heretsch Dipl.-Chem.,

    1. Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig (Germany), Fax: (+49) 341-973-6599
    Search for more papers by this author
  • Vasiliki Sarli Dr.,

    1. Laboratory of Organic Chemistry, Department of Chemistry, University of Thessaloniki, 54124 Thessaloniki (Greece)
    Search for more papers by this author
  • Anne Stößel Dipl.-Chem.

    1. Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig (Germany), Fax: (+49) 341-973-6599
    Search for more papers by this author

Abstract

original image

A biomimetic synthesis of the potent anticancer drug cyclopamine that features a C[BOND]H activation/hydroxylation and a ring contraction/expansion is described by A. Giannis and co-workers in their Communication on page 7911 ff. The picture shows the structure of cyclopamine, the first inhibitor of hedgehog signaling (discovered in drosophilia); Veratrum californicum; a cyclopic sheep; and Homer, who first reported a cyclops in the Odyssey.

Ancillary