This work was supported by Grants-in-Aid for Scientific Research from MEXT (Japan) (grant nos. 20675002, 19028015, and 21⋅7999). We thank Solvias AG for the gift of walphos ligands (R,R)-5 and (R,R)-6, Takasago Int. Co. for the gift of (R)-segphos, and Umicore for generous support in supplying a rhodium complex.
Synthesis of Chiral Tetrasubstituted Alkenes by an Asymmetric Cascade Reaction Catalyzed Cooperatively by Cationic Rhodium(I) and Silver(I) Complexes†
Article first published online: 22 SEP 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 43, pages 8129–8132, October 12, 2009
How to Cite
Hojo, D., Noguchi, K. and Tanaka, K. (2009), Synthesis of Chiral Tetrasubstituted Alkenes by an Asymmetric Cascade Reaction Catalyzed Cooperatively by Cationic Rhodium(I) and Silver(I) Complexes. Angew. Chem. Int. Ed., 48: 8129–8132. doi: 10.1002/anie.200904024
- Issue published online: 7 OCT 2009
- Article first published online: 22 SEP 2009
- Manuscript Received: 21 JUL 2009
- MEXT (Japan)
- asymmetric catalysis;
- cascade reactions;
- helical chirality;
Fantastic four: Tetrasubstituted alkenes have been prepared with high enantioselectivity by the title transformation. This reaction was successfully applied to the enantio- and diastereoselective synthesis of tetrasubstituted helical alkenes possessing both central and helical chirality (see scheme).