Biocatalytic Access to α,α-Dialkyl-α-amino Acids by a Mechanism-Based Approach


  • The Austrian Science Fund (FWF, within the project W901-B05 DK Molecular Enzymology) and the Austrian Research Promotion Agency (FFG, wthin the Kplus program) are acknowledged for financial support. We thank Prof. Harald Gröger, University Erlangen–Nürnberg, for providing us with reference samples of α-methylthreonine and C. Illaszewicz-Trattner for measuring NMR spectra.


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New donors—new products: Threonine aldolases (L-TA, D-TA) have now been found to accept donors other than glycine. In a simple asymmetric biocatalytic aldol reaction alanine, serine, and cysteine reacted with a range of simple acceptor aldehydes to yielded α-substituted serine derivatives (see scheme; PLP=pyridoxal phosphate).