Communication

Deprotonation of the Asp1[BOND]Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH†

  1. Christelle Hureau Dr.1,2,
  2. Yannick Coppel Dr.1,2,
  3. Pierre Dorlet Dr.3,4,
  4. Pier Lorenzo Solari Dr.5,
  5. Stéphanie Sayen Dr.6,
  6. Emmanuel Guillon Prof. Dr.6,
  7. Laurent Sabater Dr.1,2,
  8. Peter Faller Prof. Dr.1,2

Article first published online: 10 NOV 2009

DOI: 10.1002/anie.200904512

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 50, pages 9522–9525, December 7, 2009

Additional Information

How to Cite

Hureau, C., Coppel, Y., Dorlet, P., Solari, P. L., Sayen, S., Guillon, E., Sabater, L. and Faller, P. (2009), Deprotonation of the Asp1[BOND]Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH. Angew. Chem. Int. Ed., 48: 9522–9525. doi: 10.1002/anie.200904512

Author Information

  1. 1

    CNRS; LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, 31077 Toulouse (France)

  2. 2

    Université de Toulouse; UPS, INPT; LCC, 31077 Toulouse (France), Fax: (+33) 5-6155-3003

  3. 3

    CNRS, Laboratoire du Stress Oxydant et Détoxication, 91191 Gif-sur-Yvette (France)

  4. 4

    CEA, iBiTec-S, SB²SM, 91191 Gif-sur-Yvette (France)

  5. 5

    Synchrotron SOLEIL, 91192 Gif-sur-Yvette (France)

  6. 6

    Institut de Chimie Moléculaire de Reims (France)

  1. †

    This work was supported by a grant from the Agence Nationale de la Recherche, Programme Blanc NT09-488591, “NEUROMETALS” (P.F. and P.D.) and 05-JCJC-0010-01, “NEUROARPE” (P.D). The staff of the SAMBA beamline at SOLEIL and more particularly Dr. Emiliano Fonda are gratefully acknowledged for help in performing the XAS experiments (SOLEIL Project 20080324).

Publication History

  1. Issue published online: 30 NOV 2009
  2. Article first published online: 10 NOV 2009
  3. Manuscript Received: 12 AUG 2009

Funded by

  • Agence Nationale de la Recherche. Grant Numbers: NT09-488591, 05-JCJC-0010-01

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (338K)

Options for accessing this content:

  • If you have access to this content through a society membership, please first log in to your society website.
  • If you would like institutional access to this content, please recommend the title to your librarian.
  • Login via Athens http://onlinelibrary.wiley.com/athens or other institutional login options http://onlinelibrary.wiley.com/login-options .
  • You can purchase online access to this Article for a 24-hour period (price varies by title)
    • If you already have a Wiley Online Library or Wiley InterScience user account: login above and proceed to purchase the article.
    • New Users: Please register, then proceed to purchase the article.

Please register to:

  • Save publications, articles and searches
  • Get email alerts
  • Get all the benefits mentioned below!

Register now >

View Full Article with Supporting Information (HTML) Get PDF (338K)