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On the Chirality of Self-Assembled DNA Octahedra


  • This research was supported by the Office of Naval Research (Award No. N000140910181). DLS studies were carried out in the Purdue Laboratory for Chemical Nanotechnology (PLCN). The cryoEM images were taken in the Purdue Biological Electron Microscopy Facility, and the Purdue Rosen Center for Advanced Computing (RCAC) provided the computational resources for the 3D reconstructions.


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Why not let things go skew-whiff? A rational approach was used to program the self-assembly of a DNA octahedron (see structure; the color gradient indicates the distance from the center of the octahedron). Detailed structural characterization revealed that the assembly of the nanoobjects was stereoselective (a view of a vertex is shown with the skewed cavity that provided a handle for determination of the chirality of the octahedra).