Communication

Cholesterol Secosterol Adduction Inhibits the Misfolding of a Mutant Prion Protein Fragment that Induces Neurodegeneration†

  1. Johanna C. Scheinost1,
  2. Daniel P. Witter1,
  3. Grant E. Boldt Dr.1,
  4. John Offer Dr.1,
  5. Paul Wentworth Jr. Prof.1,2

Article first published online: 6 NOV 2009

DOI: 10.1002/anie.200904524

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 50, pages 9469–9472, December 7, 2009

Additional Information

How to Cite

Scheinost, Johanna C., Witter, Daniel P., Boldt, Grant E., Offer, J. and Wentworth, P. (2009), Cholesterol Secosterol Adduction Inhibits the Misfolding of a Mutant Prion Protein Fragment that Induces Neurodegeneration. Angew. Chem. Int. Ed., 48: 9469–9472. doi: 10.1002/anie.200904524

Author Information

  1. 1

    The Scripps-Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd., Oxford OX13QU (UK), Fax: (+44) 1865-285-329 http://www2.bioch.ox.ac.uk/wentworthlab

  2. 2

    Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla CA 92037 (USA)

  1. †

    This work was supported by the NIH AG028300 (P.W.) and by a grant from The Scripps Research Institute. The authors would like to thank R. P. Troseth (TSRI) for synthesis of 1 and Dr. P. R. Antrobus (OU) for high-resolution ES-MS of the synthetic peptides.

Publication History

  1. Issue published online: 30 NOV 2009
  2. Article first published online: 6 NOV 2009
  3. Manuscript Received: 13 AUG 2009

Funded by

  • NIH. Grant Number: AG028300
  • The Scripps Research Institute

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