Communication

Highly Stable Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic α/β-Peptides at the Air–Water Interface†

  1. Shlomit Segman2,
  2. Myung-ryul Lee1,
  3. Vladimir Vaiser2,
  4. Samuel H. Gellman Prof. Dr.1,
  5. Hanna Rapaport Dr.2

Article first published online: 18 DEC 2009

DOI: 10.1002/anie.200904566

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 49, Issue 4, pages 716–719, January 18, 2010

Additional Information

How to Cite

Segman, S., Lee, M.-r., Vaiser, V., Gellman, Samuel H. and Rapaport, H. (2010), Highly Stable Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic α/β-Peptides at the Air–Water Interface. Angew. Chem. Int. Ed., 49: 716–719. doi: 10.1002/anie.200904566

Author Information

  1. 1

    Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI 53706 (USA)

  2. 2

    Department of Biotechnology Engineering, Ben Gurion University of the Negev, PO Box 653, Beer-Sheva 84105 (Israel), Fax: (+972) 8-6472983

  1. †

    This work was supported by the United States–Israel Binational Science Foundation (Grant No. 2005132). M.-r.L. was supported by a Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-214-C00053) and by the Nanoscale Science and Engineering Center at UW-Madison (NSF DMR-0425880). GIXD studies at beam-line BW1, Hasylab, DESY, were supported by the European Community-Research Infrastructure Action under the FP6 “Structuring the European Research Area” Programme (through the Integrated Infrastructure Initiative “Integrating Activity on Synchrotron and Free Electron Laser Science”).

Publication History

  1. Issue published online: 13 JAN 2010
  2. Article first published online: 18 DEC 2009
  3. Manuscript Received: 16 AUG 2009

Funded by

  • United States–Israel Binational Science Foundation. Grant Number: 2005132
  • Korean Government (MOEHRD). Grant Number: KRF-2006-214-C00053
  • Nanoscale Science and Engineering Center at UW-Madison. Grant Number: NSF DMR-0425880

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Keywords:

  • β-sheet;
  • foldamers;
  • monolayers;
  • peptides;
  • self-assembly
Thumbnail image of graphical abstract

A nice gathering at the interface: The de novo design and characterization of amphiphilic α/β-peptides, which form ordered two-dimensional assemblies at the air–water interface composed of oligomers in pleated conformation similar to β-sheets of α-peptides, is reported. The positioning of ionic side chains along the backbone can exert a profound effect on the propensity to self-assemble.

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