Multistep Microchemical Synthesis Enabled by Microfluidic Distillation


  • K.F.J. and S.L.B. thank the Novartis International AG for funding.


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Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid–liquid extraction, and microfluidic distillation. The microfluidic distillation enabled solvent exchange from CH2Cl2 in the first reaction step to N,N-dimethylformamide (DMF) in the final reaction step.