K.F.J. and S.L.B. thank the Novartis International AG for funding.
Multistep Microchemical Synthesis Enabled by Microfluidic Distillation†
Article first published online: 18 DEC 2009
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 5, pages 899–903, January 25, 2010
How to Cite
Hartman, Ryan L., Naber, John R., Buchwald, Stephen L. and Jensen, Klavs F. (2010), Multistep Microchemical Synthesis Enabled by Microfluidic Distillation. Angew. Chem. Int. Ed., 49: 899–903. doi: 10.1002/anie.200904634
- Issue published online: 19 JAN 2010
- Article first published online: 18 DEC 2009
- Manuscript Revised: 19 NOV 2009
- Manuscript Received: 20 AUG 2009
- Heck reaction;
- microfluidic distillation;
- synthetic methods
Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid–liquid extraction, and microfluidic distillation. The microfluidic distillation enabled solvent exchange from CH2Cl2 in the first reaction step to N,N-dimethylformamide (DMF) in the final reaction step.