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Keywords:

  • Heck reaction;
  • microfluidic distillation;
  • microreactors;
  • palladium;
  • synthetic methods
Thumbnail image of graphical abstract

Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid–liquid extraction, and microfluidic distillation. The microfluidic distillation enabled solvent exchange from CH2Cl2 in the first reaction step to N,N-dimethylformamide (DMF) in the final reaction step.