Efficient and Selective Room-Temperature Gold-Catalyzed Reduction of Nitro Compounds with CO and H2O as the Hydrogen Source

Authors

  • Lin He,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • Lu-Cun Wang Dr.,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • Hao Sun,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • Ji Ni,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • Yong Cao Prof.,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • He-Yong He Prof.,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • Kang-Nian Fan Prof.

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (China), Fax: (+86) 21-6564-3774
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  • We thank the NSF of China (20633030, 20721063, and 20873026), the State Key Basic Research Program of PRC (2009CB623506), the Science & Technology Commission of Shanghai Municipality (08DZ2270500, 07QH14003), and the Shanghai Education Committee (06SG03) for financial support.

Abstract

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Taking hydrogen from water: Gold catalysis enabled the selective reduction of nitro compounds under very mild conditions with a combination of H2O and CO as the reductant (see scheme). This environmentally friendly reaction proceeded in high yield and with high chemoselectivity in the presence of a wide range of functional groups.

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