The authors acknowledge financial support from the National Institutes of Health (CA-115531, CA-126608, RR-02584 and EB-004582) and the Robert A. Welch Foundation (AT-584) as well as the Deisenhofer Laboratory at UT Southwestern Medical Center for use of computational resources. DOTA=1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane.
Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands†
Article first published online: 5 NOV 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 49, pages 9330–9333, November 23, 2009
How to Cite
Viswanathan, S., Ratnakar, S. James., Green, Kayla N., Kovacs, Z., De León-Rodríguez, Luis M. and Sherry, A. Dean. (2009), Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands. Angew. Chem. Int. Ed., 48: 9330–9333. doi: 10.1002/anie.200904649
- Issue published online: 17 NOV 2009
- Article first published online: 5 NOV 2009
- Manuscript Received: 20 AUG 2009
- National Institutes of Health. Grant Numbers: CA-115531, CA-126608, RR-02584, EB-004582
- Robert A. Welch Foundation. Grant Number: AT-584
- imaging agents;
- saturation transfer
Colorful palette: A new class of highly selective Eu3+-based multi-frequency PARACEST agents is reported. The complexes can be tuned when administered simultaneously thereby allowing for the possibility of monitoring multiple biomarkers in parallel. PARACEST = paramagnetic chemical exchange saturation transfer.