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Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands

Authors

  • Subha Viswanathan Dr.,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
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  • S. James Ratnakar Dr.,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
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  • Kayla N. Green Dr.,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
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  • Zoltan Kovacs Prof.,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
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  • Luis M. De León-Rodríguez Prof.,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
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  • A. Dean Sherry Prof.

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 (USA), Fax: (+1) 214-645-2744
    2. Department of Chemistry, University of Texas, Dallas, 800 West Campbell Road, Richardson, Texas, 75080 (USA)
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  • The authors acknowledge financial support from the National Institutes of Health (CA-115531, CA-126608, RR-02584 and EB-004582) and the Robert A. Welch Foundation (AT-584) as well as the Deisenhofer Laboratory at UT Southwestern Medical Center for use of computational resources. DOTA=1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane.

Abstract

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Colorful palette: A new class of highly selective Eu3+-based multi-frequency PARACEST agents is reported. The complexes can be tuned when administered simultaneously thereby allowing for the possibility of monitoring multiple biomarkers in parallel. PARACEST = paramagnetic chemical exchange saturation transfer.

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