Multimodal Gadolinium-Enriched DNA–Gold Nanoparticle Conjugates for Cellular Imaging

Authors

  • Ying Song,

    1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
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    • These authors contributed equally to this work.

  • Xiaoyang Xu,

    1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
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    • These authors contributed equally to this work.

  • Keith W. MacRenaris,

    1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
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  • Xue-Qing Zhang Dr.,

    1. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 (USA)
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  • Chad A. Mirkin Prof.,

    1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
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  • Thomas J. Meade Prof.

    1. Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
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  • We acknowledge financial support of the NCI/CCNE grant no. CA119341 and NIH grant no. R01EB005866. We thank E. Alex Waters for help with the 3T solution phantom images.

Abstract

original image

Conjugate agent: A GdIII enriched DNA-AuNP conjugate for intracellular magnetic resonance and fluorescence imaging is reported. The agent exhibits high relaxivity per particle and high cell uptake properties that provide a means to image and map small cell populations.

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