Get access

Asymmetric Dehydrative Cyclization of ω-Hydroxy Allyl Alcohols Catalyzed by Ruthenium Complexes


  • This work was supported by the Grant-in-Aid for Scientific Research (no. 25E07B212) from the Ministry of Education, Science, Sports, and Culture (Japan).


original image

New axially chiral ligands and their allyl esters have been designed and synthesized. The combination of these ligands with [CpRu(CH3CN)3]PF6 has realized highly efficient intramolecular dehydrative cylization of ω-hydroxy allyl alcohols, to give α-alkenyl-substituted cyclic ethers with up to greater than 99:1 enantiomeric ratio without activation of the allylic moieties (see scheme; Cp=cyclopentadienyl, naph=naphthyl, py=pyridine).