Communication

A Convenient and General Iron-Catalyzed Reduction of Amides to Amines†

  1. Shaolin Zhou,
  2. Kathrin Junge Dr.,
  3. Daniele Addis,
  4. Shoubhik Das,
  5. Matthias Beller Prof. Dr.

Article first published online: 25 SEP 2009

DOI: 10.1002/anie.200904677

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 50, pages 9507–9510, December 7, 2009

Additional Information

How to Cite

Zhou, S., Junge, K., Addis, D., Das, S. and Beller, M. (2009), A Convenient and General Iron-Catalyzed Reduction of Amides to Amines. Angew. Chem. Int. Ed., 48: 9507–9510. doi: 10.1002/anie.200904677

Author Information

  1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-51113 http://www.catalysis.de

  1. †

    This work has been funded by the State of Mecklenburg-Western Pomerania, the BMBF, the DFG (Leibniz prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, A. Kammer, A. Koch, S. Rossmeisl, and K. Mevius (all at the LIKAT) for their excellent technical and analytical support.

Publication History

  1. Issue published online: 30 NOV 2009
  2. Article first published online: 25 SEP 2009
  3. Manuscript Received: 22 AUG 2009

Funded by

  • State of Mecklenburg-Western Pomerania
  • BMBF
  • DFG

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Keywords:

  • amides;
  • amines;
  • homogeneous catalysis;
  • iron;
  • reduction
Thumbnail image of graphical abstract

While the iron is hot: The first general and efficient iron-catalyzed reduction of secondary and tertiary amides into amines using polymethylhydrosiloxane (PMHS) has been developed (see scheme).

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