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Activation of Allylic C[BOND]F bonds: Palladium-Catalyzed Allylic Amination of 3,3-Difluoropropenes

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  • This work was supported by the Canada Research Chairs Program, the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the Fonds de recherche sur la nature et les technologies, Pfizer Global Research & Development, and the Université Laval. OmegaChem Inc. is thanked for a generous gift of 3,3-difluoropyrrolidine hydrochloride.

Abstract

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Lose one, keep one! A wide range of cyclic and acyclic β-aminofluoroalkenes are prepared by the title reaction. The key fluorinated palladium π-allyl intermediate is generated using a catalytic allylic C[BOND]F bond activation.

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