We are grateful to the National Science Foundation of China (20672040 and 20872043) and the Program for Academic Leader in Wuhan Municipality (200851430486) for the support of this research. We thank Dr. Richard Pederson and Dr. Joel Austin for fruitful discussions.
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Communication
Construction of Fused Heterocyclic Architectures by Formal [4+1]/[3+2] Cycloaddition Cascade of Sulfur Ylides and Nitroolefins†
Article first published online: 10 NOV 2009
DOI: 10.1002/anie.200904766
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Lu, L.-Q., Li, F., An, J., Zhang, J.-J., An, X.-L., Hua, Q.-L. and Xiao, W.-J. (2009), Construction of Fused Heterocyclic Architectures by Formal [4+1]/[3+2] Cycloaddition Cascade of Sulfur Ylides and Nitroolefins. Angew. Chem. Int. Ed., 48: 9542–9545. doi: 10.1002/anie.200904766
- †
Publication History
- Issue published online: 30 NOV 2009
- Article first published online: 10 NOV 2009
- Manuscript Received: 26 AUG 2009
Funded by
- National Science Foundation of China. Grant Numbers: 20672040, 20872043
- Program for Academic Leader in Wuhan Municipality. Grant Number: 200851430486
Keywords:
- cascade reaction;
- cycloaddition;
- nitroolefins;
- sulfur ylides
Under control: A formal [4+1]/[3+2] cycloaddition cascade of sulfur ylides and alkene-tethered nitroolefins has been developed, and provides an efficient synthesis of fused polycyclic heterocyclic compounds in good to excellent overall yields with excellent diastereocontrol (see scheme). A catalytic asymmetric variant of this reaction has also been disclosed.