The Région Ile-de-France (doctoral grant for F. B.) and the Agence Nationale de la Recherche are thanked for financial support. We acknowledge the Institut de Chimie des Substances Naturelles—CNRS (Gif sur Yvette) for use of the X-ray facility and thank Dr. Pascal Retailleau from the Service de Cristallochimie for the crystal structure solution.
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Communication
Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles†
Article first published online: 9 NOV 2009
DOI: 10.1002/anie.200904776
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Besselièvre, F. and Piguel, S. (2009), Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles. Angew. Chem. Int. Ed., 48: 9553–9556. doi: 10.1002/anie.200904776
- †
Publication History
- Issue published online: 30 NOV 2009
- Article first published online: 9 NOV 2009
- Manuscript Received: 26 AUG 2009
Funded by
- Région Ile-de-France
- Agence Nationale de la Recherche
- CNRS
Keywords:
- alkynes;
- alkynylation;
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H activation; - copper;
- heterocycles
Copper-bottomed catalysis! The direct alkynylation of azoles through a copper-based CH bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional-group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementary to the Sonogashira reaction.